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• New tool to dissect 'undruggable' proteins through the sugars they depend on
• Exhaustion linked with increased risk of heart attack in men
• Oil in the ocean photooxides within hours to days, new study finds
• Cancer cells may evade chemotherapy by going dormant
• Vaccine-induced antibodies may be less effective against several new SARS-CoV-2 variants

New tool to dissect 'undruggable' proteins through the sugars they depend on Posted: 13 Mar 2021 12:19 PM PST Researchers have developed a new tool to study 'undruggable' proteins through the sugars they depend on. Almost 85 percent of proteins, including those associated with Alzheimer's, Parkinson's, inflammation, and certain cancers, are beyond the reach of current drugs. Now, with a new pencil/eraser tool, researchers can start to study how sugar molecules affect these proteins, insights that could lead to new treatments for the 'undruggable.'

Exhaustion linked with increased risk of heart attack in men Posted: 13 Mar 2021 12:19 PM PST Men experiencing vital exhaustion are more likely to have a heart attack, according to new research.

Oil in the ocean photooxides within hours to days, new study finds Posted: 12 Mar 2021 03:11 PM PST A new study demonstrates that under realistic environmental conditions oil drifting in the ocean after the DWH oil spill photooxidized into persistent compounds within hours to days, instead over long periods of time as was thought during the 2010 Deepwater Horizon oil spill. This is the first model results to support the new paradigm of photooxidation that emerged from laboratory research.

Cancer cells may evade chemotherapy by going dormant Posted: 12 Mar 2021 03:11 PM PST Cancer cells can dodge chemotherapy by entering a state that bears similarity to certain kinds of senescence, a type of 'active hibernation' that enables them to weather the stress induced by aggressive treatments aimed at destroying them, according to a new study. These findings have implications for developing new drug combinations that could block senescence and make chemotherapy more effective.

Vaccine-induced antibodies may be less effective against several new SARS-CoV-2 variants Posted: 12 Mar 2021 11:00 AM PST Researchers find that neutralizing antibodies raised by COVID-19 vaccines are not as effective at neutralizing some new, circulating SARS-CoV-2 variants.

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